產品貨號 :  mlR21360 

英文名稱 :  SLC40A1 

中文名稱 :  細胞膜鐵轉運蛋白FP1抗體 

別    名 :  Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.   

研究領域 :  腫瘤  免疫學  信號轉導  轉錄調節因子   

抗體來源 :  Rabbit

克隆類型 :  Polyclonal 

交叉反應 :   Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 

產品應用 :  WB=1:500-2000 ELISA=1:500-1000  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  63kDa 

細胞定位 :  細胞膜 

性    狀 :  Lyophilized or Liquid 

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human SLC40A1:31-130/571

亞    型 :  IgG 

純化方法 :  affinity purified by Protein A 

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

PubMed :  PubMed

產品介紹 :   SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. 

Function:

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subcellular Location:

Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. 

Tissue Specificity:

Expressed in placenta, intestine, muscle and spleen. 

DISEASE:

Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. 

Similarity:

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. 

SWISS:

Q9NP59

Gene ID:

30061 

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.