產(chǎn)品貨號(hào) :  mlR8809

英文名稱(chēng) :  HMG4/HMGB3

中文名稱(chēng) :  高遷移率家族蛋白3抗體

別    名 :  High mobility group (nonhistone chromosomal) protein 4; High mobility group box 3; High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; High mobility group protein HMG4; HMG 4; HMG-2a; HMG-4; HMG2A; HMGB 3; HMGB3; HMGB3_HUMAN; MGC90319; Non histone chromosomal protein; Nonhistone chromosomal protein HMG4.  

研究領(lǐng)域 :  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  表觀遺傳學(xué)  

抗體來(lái)源 :  Rabbit

克隆類(lèi)型 :  Polyclonal

交叉反應(yīng) :  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

產(chǎn)品應(yīng)用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  23kDa

細(xì)胞定位 :  細(xì)胞核

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human HMG4/HMGB3:1-100/200

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲(chǔ) 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產(chǎn)品介紹 :  HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 [PubMed 9370291]; Nemeth et al., 2006 [PubMed 16945912]).[supplied by OMIM, Mar 2008]

Function:

Binds preferentially single-stranded DNA and unwinds double stranded DNA.

Subcellular Location:

Nucleus. Chromosome.

Tissue Specificity:

Expressed predominantly in placenta.

Similarity:

Belongs to the HMGB family.

Contains 2 HMG box DNA-binding domains.

SWISS:

O15347

Gene ID:

3149

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.