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黑色素瘤相關(guān)抗原3抗體

  • 產(chǎn)品貨號(hào):mlR18617-1 收藏此商品
  • 銷(xiāo)售價(jià):1580.00-2480.00
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產(chǎn)品號(hào) :  mlR18617

英文名稱(chēng) :  MAGEA3

中文名稱(chēng) :  黑色素瘤相關(guān)抗原3抗體

    :  Antigen MZ2 D; Antigen MZ2-D; Cancer/testis antigen 1.3; Cancer/testis antigen family 1 member 3; CT1.3; HIP8; HYPD; MAGA3_HUMAN; MAGE 3 antigen; MAGE-3 antigen; MAGE3; MAGEA3; MAGEA6; Melanoma antigen family A 3; Melanoma associated antigen 3; Melanoma-associated antigen 3; MGC1461.  

研究領(lǐng)域 :  腫瘤  細(xì)胞生物  

抗體來(lái)源 :  Rabbit

克隆類(lèi)型 :  Polyclonal

交叉反應(yīng) :  Human,

產(chǎn)品應(yīng)用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

:  35kDa

細(xì)胞定位 :  細(xì)胞漿

    :  Lyophilized or Liquid

    :  1mg/ml

:  KLH conjugated synthetic peptide derived from human MAGEA3:231-314/314

    :  IgG

純化方法 :  affinity purified by Protein A

儲(chǔ) :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產(chǎn)品介紹  :  This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Function:

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Tissue Specificity:

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.

Similarity:

Contains 1 MAGE domain.

SWISS:

P43357

Gene ID:

4102

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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