產品貨號 :  mlR18619

英文名稱 :  MAGEA8

中文名稱 :  黑色素瘤相關抗原8抗體

別    名 :  Cancer/testis antigen 1.8; CT1.8; MAGA8_HUMAN; MAGE 8 antigen; MAGE-8 antigen; MAGE8 antigen; MAGEA8; Melanoma antigen family A 8; Melanoma associated antigen 8; Melanoma-associated antigen 8; MGC2182.  

研究領域 :  腫瘤  細胞生物  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應 :  Human,

產品應用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  35kDa

細胞定位 :  細胞漿

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MAGEA8:1-100/318

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產品介紹 :   This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]

Function:

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Tissue Specificity:

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta.

Similarity:

Contains 1 MAGE domain.

SWISS:

P43361

Gene ID:

4107

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.